Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations in
Byron C. Knowles, Joseph T. Roland, Moorthy Krishnan, Matthew J. Tyska, Lynne A. Lapierre, Paul S. Dickman, James R. Goldenring, Mitchell D. Shub
MYO5B-WT and MYO5B-YE/QR rescue the MYO5B-KD phenotype, while MYO5B-P660L and MYO5B-YE/QR promote microvillus inclusions.