Cell-to-cell interaction is required to induce proteinuria in in situ immune complex glomerulonephritis
T Oda, M Kimura, A Hishida, A Yamashita… - Journal of Laboratory …, 1998 - Elsevier
This experiment was performed to study the roles of intercellular adhesion molecule-1
(ICAM-1), lymphocyte function-associated antigen-1 (LFA-1), and another adhesion
molecule, selectin, in the development of cationized antigen-induced in situ immune
complex glomerulonephritis (CAICGN). CAICGN was induced in preimmunized rats by
perfusing cationized human immunoglobulin G (CaIgG) through the left kidney. Albuminuria
developed within 2 days of CaIgG perfusion and peaked around day 7. Marked …
(ICAM-1), lymphocyte function-associated antigen-1 (LFA-1), and another adhesion
molecule, selectin, in the development of cationized antigen-induced in situ immune
complex glomerulonephritis (CAICGN). CAICGN was induced in preimmunized rats by
perfusing cationized human immunoglobulin G (CaIgG) through the left kidney. Albuminuria
developed within 2 days of CaIgG perfusion and peaked around day 7. Marked …
