Mechanisms of p53-mediated apoptosis
HF Ding, DE Fisher - Critical Reviews™ in Oncogenesis, 1998 - dl.begellhouse.com
HF Ding, DE Fisher
Critical Reviews™ in Oncogenesis, 1998•dl.begellhouse.comABSTRACT p53-mediated apoptosis of cells with DNA damage or oncogene
overexpression is a major mechanism for its function as a tumor suppressor. Both
transcriptionally dependent and transcriptionally independent activities of p53 can play a
role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways
in a manner which is regulated in a cell type and signal-specific fashion. Understanding the
biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating …
overexpression is a major mechanism for its function as a tumor suppressor. Both
transcriptionally dependent and transcriptionally independent activities of p53 can play a
role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways
in a manner which is regulated in a cell type and signal-specific fashion. Understanding the
biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating …
Abstract
p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.
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