Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
N Heisterkamp, JR Stephenson, J Groffen, PF Hansen… - Nature, 1983 - nature.com
N Heisterkamp, JR Stephenson, J Groffen, PF Hansen, A de Klein, CR Bartram, G Grosveld
Nature, 1983•nature.comThe human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is
translocated to chromosome 22, the Philadelphia (Ph′) chromosome, in chronic myelocytic
leukaemia (CML). The position of the Ph′ chromosomal break point is shown to be variable
and, in one CML patient, has been localized immediately 5′ of, or within, the c-abl
oncogene. A DNA restriction fragment corresponding to this site has been molecularly
cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.
translocated to chromosome 22, the Philadelphia (Ph′) chromosome, in chronic myelocytic
leukaemia (CML). The position of the Ph′ chromosomal break point is shown to be variable
and, in one CML patient, has been localized immediately 5′ of, or within, the c-abl
oncogene. A DNA restriction fragment corresponding to this site has been molecularly
cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.
Abstract
The human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph′) chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph′ chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5′ of, or within, the c-abl oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.
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