Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone
S Larkin, E Mull, W Miao, R Pittner, K Albrandt… - Biochemical and …, 1997 - Elsevier
S Larkin, E Mull, W Miao, R Pittner, K Albrandt, C Moore, A Young, M Denaro, K Beaumont
Biochemical and biophysical research communications, 1997•ElsevierUncoupling protein (UCP1) is a transmembrane proton transporter present in the
mitochondria of brown adipose tissue (BAT), a specialized tissue which functions in
temperature homeostasis and energy balance (Nicholls, DG, and Locke, RM (1984) Physiol.
Rev. 64, 2–40; Lowell, DD, and Flier, JS (1997) Annu. Rev. Med.). UCP1 mediates the
thermogenesis that is characteristic of BAT by uncoupling mitochondrial oxidation of
substrates from ATP synthesis. Recently, two proteins related to UCP1 have been identified …
mitochondria of brown adipose tissue (BAT), a specialized tissue which functions in
temperature homeostasis and energy balance (Nicholls, DG, and Locke, RM (1984) Physiol.
Rev. 64, 2–40; Lowell, DD, and Flier, JS (1997) Annu. Rev. Med.). UCP1 mediates the
thermogenesis that is characteristic of BAT by uncoupling mitochondrial oxidation of
substrates from ATP synthesis. Recently, two proteins related to UCP1 have been identified …
Uncoupling protein (UCP1) is a transmembrane proton transporter present in the mitochondria of brown adipose tissue (BAT), a specialized tissue which functions in temperature homeostasis and energy balance (Nicholls, D. G., and Locke, R. M. (1984)Physiol. Rev.64, 2–40; Lowell, D. D., and Flier, J. S. (1997)Annu. Rev. Med.). UCP1 mediates the thermogenesis that is characteristic of BAT by uncoupling mitochondrial oxidation of substrates from ATP synthesis. Recently, two proteins related to UCP1 have been identified and designated UCP2 (Fleury, C.,et al.(1997)Nature Genetics15, 269–272) or UCP homolog (UCPH) (Gimeno, R. E.,et al.(1997)Diabetes46, 900–906) and UCP3 (Boss, O.,et al.(1997)FEBS Lett.408, 39–42; Vidal-Puig, A.,et al.(1997)Biochem. Biophys. Res. Commun.235, 79–82). We investigated the regulation in rats of UCP3, which is expressed primarily in skeletal muscle and BAT. Expression of rat UCP3 mRNA in BAT was upregulated by in vivo treatment with triiodothyronine (T3) and by exposure to cold, suggesting that UCP3 is active in thermogenesis and energy expenditure. In skeletal muscle, UCP3 mRNA was also upregulated by T3but, surprisingly, not by cold exposure. A hypothesis is proposed to account for this differential regulation.
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