[HTML][HTML] Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor
N Giannoukakis, WA Rudert, M Trucco… - Journal of Biological …, 2000 - ASBMB
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell function and promotes
Fas-triggered apoptosis. IL-1β is thought to act early in the initiation of the autoimmune
destruction of pancreatic β cells in type I diabetes. IL-1β promotes β cell impairment, in part,
by activating NF-κB transcription factor-dependent signaling pathways. We have examined
whether β cells could be protected from the effects of IL-1β by overexpressing an inhibitor of
NF-κB activity, IκB, by adenoviral gene transfer to intact human islets in culture. Infection of …
Fas-triggered apoptosis. IL-1β is thought to act early in the initiation of the autoimmune
destruction of pancreatic β cells in type I diabetes. IL-1β promotes β cell impairment, in part,
by activating NF-κB transcription factor-dependent signaling pathways. We have examined
whether β cells could be protected from the effects of IL-1β by overexpressing an inhibitor of
NF-κB activity, IκB, by adenoviral gene transfer to intact human islets in culture. Infection of …