[HTML][HTML] Processing by endoplasmic reticulum mannosidases partitions a secretion-impaired glycoprotein into distinct disposal pathways
CM Cabral, P Choudhury, Y Liu, RN Sifers - Journal of Biological Chemistry, 2000 - ASBMB
In the early secretory pathway, a distinct set of processing enzymes and family of lectins
facilitate the folding and quality control of newly synthesized glycoproteins. In this regard, we
recently identified a mechanism in which processing by endoplasmic reticulum
mannosidase I, which attenuates the removal of glucose from asparagine-linked
oligosaccharides, sorts terminally misfolded α 1-antitrypsin for proteasome-mediated
degradation in response to its abrogated physical dissociation from calnexin (Liu, Y …
facilitate the folding and quality control of newly synthesized glycoproteins. In this regard, we
recently identified a mechanism in which processing by endoplasmic reticulum
mannosidase I, which attenuates the removal of glucose from asparagine-linked
oligosaccharides, sorts terminally misfolded α 1-antitrypsin for proteasome-mediated
degradation in response to its abrogated physical dissociation from calnexin (Liu, Y …
