Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
TN Sato, Y Qin, CA Kozak… - Proceedings of the …, 1993 - National Acad Sciences
TN Sato, Y Qin, CA Kozak, KL Audus
Proceedings of the National Academy of Sciences, 1993•National Acad SciencesWe report the molecular cloning and characterization of two structurally related putative
receptor tyrosine kinases, encoded by distinct genes (tie-1 and tie-2) on mouse
chromosome 4. Both tie-1 and tie-2 encode receptor proteins possessing unique multiple
extracellular domains: two immunoglobulin-like loop domains flanking three epidermal
growth factor repeats followed by three fibronectin-type III repeats. Both genes are
expressed in early embryonic vascular system and in maternal decidual vascular …
receptor tyrosine kinases, encoded by distinct genes (tie-1 and tie-2) on mouse
chromosome 4. Both tie-1 and tie-2 encode receptor proteins possessing unique multiple
extracellular domains: two immunoglobulin-like loop domains flanking three epidermal
growth factor repeats followed by three fibronectin-type III repeats. Both genes are
expressed in early embryonic vascular system and in maternal decidual vascular …
We report the molecular cloning and characterization of two structurally related putative receptor tyrosine kinases, encoded by distinct genes (tie-1 and tie-2) on mouse chromosome 4. Both tie-1 and tie-2 encode receptor proteins possessing unique multiple extracellular domains: two immunoglobulin-like loop domains flanking three epidermal growth factor repeats followed by three fibronectin-type III repeats. Both genes are expressed in early embryonic vascular system and in maternal decidual vascular endothelial cells, where the vasculature undergoes an active angiogenesis. tie-2, but not tie-1, expression was also detected in extraembryonic mesoderm of the amnion. tie-1, but not tie-2, is expressed in an acute myelogenic cell line in vitro. tie-1 and tie-2 may form another class within the receptor tyrosine kinase gene family, and further characterization of these genes and identification of their putative ligands should define the nature of the signal-transduction cascades underlying early vascular system development, as well as their differential roles in mesodermal cells of the amniotic and myeloid lineages.
National Acad Sciences