[HTML][HTML] Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes
B Kern, J Shen, M Starbuck, G Karsenty - Journal of Biological Chemistry, 2001 - ASBMB
Type I collagen is composed of two chains, α1 (I) and α2 (I), encoded by two distinct genes,
the α1 (I) and α2 (I) collagen genes, that are highly expressed in osteoblasts. In most
physiological situations, α1 (I) and α2 (I) collagen expression is coregulated, suggesting that
identical transcription factors control their expression. Here, we studied the role of Cbfa1, an
osteoblast-specific transcription factor, in the control of α1 (I) and α2 (I) collagen expression
in osteoblasts. A consensus Cbfa1-binding site, termed OSE2, is present at the same …
the α1 (I) and α2 (I) collagen genes, that are highly expressed in osteoblasts. In most
physiological situations, α1 (I) and α2 (I) collagen expression is coregulated, suggesting that
identical transcription factors control their expression. Here, we studied the role of Cbfa1, an
osteoblast-specific transcription factor, in the control of α1 (I) and α2 (I) collagen expression
in osteoblasts. A consensus Cbfa1-binding site, termed OSE2, is present at the same …
