Hyperprolactinemia in male NZB/NZW (B/W) F1 mice: accelerated autoimmune disease with normal circulating testosterone
R McMurray, D Keisler, S Izui, SE Walker - Clinical immunology and …, 1994 - Elsevier
It has been proposed that the immunostimulatory hormone, prolactin, is associated with
flares of systemic lupus erythematosus (SLE). In autoimmune female NZB/NZW F1 (B/W)
mice with accelerated lupus-like disease, hyperprolactinemia accelerated autoimmunity.
The current study explored effects of moderate and severe hyperprolactinemia in male B/W
mice, which have late-onset SLE. Autoimmune disease in B/W males was assessed by
measurement of anti-DNA antibodies (anti-DNA), gp70-anti-gp70 immune complexes …
flares of systemic lupus erythematosus (SLE). In autoimmune female NZB/NZW F1 (B/W)
mice with accelerated lupus-like disease, hyperprolactinemia accelerated autoimmunity.
The current study explored effects of moderate and severe hyperprolactinemia in male B/W
mice, which have late-onset SLE. Autoimmune disease in B/W males was assessed by
measurement of anti-DNA antibodies (anti-DNA), gp70-anti-gp70 immune complexes …