[HTML][HTML] Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17
B Kalbfuss, SA Mabon, T Misteli - Journal of Biological Chemistry, 2001 - ASBMB
Mutations in the human tau gene cause frontotemporal dementia and Parkinsonism
associated with chromosome 17 (FTDP-17). One of the major disease mechanisms in FTDP-
17 is the increased inclusion of tau exon 10 during pre-mRNA splicing. Here we show that
modified oligonucleotides directed against the tau exon 10 splice junctions suppress
inclusion of tau exon 10. The effect is mediated by the formation of a stable pre-mRNA-
oligonucleotide hybrid, which blocks access of the splicing machinery to the pre-mRNA …
associated with chromosome 17 (FTDP-17). One of the major disease mechanisms in FTDP-
17 is the increased inclusion of tau exon 10 during pre-mRNA splicing. Here we show that
modified oligonucleotides directed against the tau exon 10 splice junctions suppress
inclusion of tau exon 10. The effect is mediated by the formation of a stable pre-mRNA-
oligonucleotide hybrid, which blocks access of the splicing machinery to the pre-mRNA …