α-OLIGONUCLEOTIDES WITH ANIONIC PHOSPHODIESTER AND CATIONIC PHOSPHORAMIDATE LINKAGES ENHANCED STABILITY OF DNA TRIPLE HELIX
F Ehrenmann, JJ Vasseur, F Debart - … , Nucleotides and Nucleic …, 2001 - Taylor & Francis
F Ehrenmann, JJ Vasseur, F Debart
Nucleosides, Nucleotides and Nucleic Acids, 2001•Taylor & FrancisSynthesis of several α-oligonucleotides containing both anionic phosphodiester and cationic
N-(dimethylaminopropyl) phosphoramidate internucleosidic linkages is described. Their
ability to form triple helix with dsDNA was evaluated at various pH by UV melting
experiments.
N-(dimethylaminopropyl) phosphoramidate internucleosidic linkages is described. Their
ability to form triple helix with dsDNA was evaluated at various pH by UV melting
experiments.
Synthesis of several α-oligonucleotides containing both anionic phosphodiester and cationic N-(dimethylaminopropyl)phosphoramidate internucleosidic linkages is described. Their ability to form triple helix with dsDNA was evaluated at various pH by UV melting experiments.
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