[HTML][HTML] Fucosylation of Cripto is required for its ability to facilitate nodal signaling
SG Schiffer, S Foley, A Kaffashan, X Hronowski… - Journal of Biological …, 2001 - ASBMB
O-Linked fucose modification is rare and has been shown to occur almost exclusively within
epidermal growth factor (EGF)-like modules. We have found that the EGF-CFC family
member human Cripto-1 (CR) is modified with fucose and through a combination of peptide
mapping, mass spectrometry, and sequence analysis localized the site of attachment to Thr-
88. The identification of a fucose modification on human CR within its EGF-like domain and
the presence of a consensus fucosylation site within all EGF-CFC family members suggest …
epidermal growth factor (EGF)-like modules. We have found that the EGF-CFC family
member human Cripto-1 (CR) is modified with fucose and through a combination of peptide
mapping, mass spectrometry, and sequence analysis localized the site of attachment to Thr-
88. The identification of a fucose modification on human CR within its EGF-like domain and
the presence of a consensus fucosylation site within all EGF-CFC family members suggest …
