[HTML][HTML] Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor …
K Kraft, H Olbrich, I Majoul, M Mack, A Proudfoot… - Journal of Biological …, 2001 - ASBMB
The CC chemokine receptor CCR5 mediates chemotaxis of leukocytes and serves as a
principal co-receptor for macrophage-tropic human immunodeficiency virus type 1. To
identify determinants on the CCR5 carboxyl-terminal domain that regulate receptor signaling
and internalization, we generated several CCR5 mutants, which were progressively
shortened from the COOH terminus or had carboxyl-terminal serine, cysteine, or leucine
residues substituted by alanine and expressed them in RBL-2H3 cells. Using fluorescence …
principal co-receptor for macrophage-tropic human immunodeficiency virus type 1. To
identify determinants on the CCR5 carboxyl-terminal domain that regulate receptor signaling
and internalization, we generated several CCR5 mutants, which were progressively
shortened from the COOH terminus or had carboxyl-terminal serine, cysteine, or leucine
residues substituted by alanine and expressed them in RBL-2H3 cells. Using fluorescence …
