[HTML][HTML] β-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor …
A Tohgo, KL Pierce, EW Choy, RJ Lefkowitz… - Journal of Biological …, 2002 - ASBMB
β-Arrestins are cytosolic proteins that mediate homologous desensitization of G protein-
coupled receptors (GPCRs) by binding to agonist-occupied receptors and by uncoupling
them from heterotrimeric G proteins. The recent finding that β-arrestins bind to some mitogen-
activated protein (MAP) kinases has suggested that they might also function as scaffolds for
GPCR-stimulated MAP kinase activation. To define the role of β-arrestins in the regulation of
ERK MAP kinases, we examined the effect of β-arrestin overexpression on ERK1/2 …
coupled receptors (GPCRs) by binding to agonist-occupied receptors and by uncoupling
them from heterotrimeric G proteins. The recent finding that β-arrestins bind to some mitogen-
activated protein (MAP) kinases has suggested that they might also function as scaffolds for
GPCR-stimulated MAP kinase activation. To define the role of β-arrestins in the regulation of
ERK MAP kinases, we examined the effect of β-arrestin overexpression on ERK1/2 …
