[HTML][HTML] A four amino acid deletion polymorphism in the third intracellular loop of the human α2C-adrenergic receptor confers impaired coupling to multiple effectors
KM Small, SL Forbes, FF Rahman, KM Bridges… - Journal of Biological …, 2000 - ASBMB
The α 2-adrenergic receptors (α 2 ARs) play a critical role in modulating neurotransmitter
release in the central and peripheral sympathetic nervous systems. A polymorphism of the α
2 AR subtype localized to human chromosome 4 (the pharmacologic α 2C AR subtype)
within an intracellular domain has been identified in normal individuals. The polymorphism
(denoted Del322–325) is because of an in-frame 12-nucleic acid deletion encoding a
receptor lacking Gly-Ala-Gly-Pro in the third intracellular loop. To delineate the functional …
release in the central and peripheral sympathetic nervous systems. A polymorphism of the α
2 AR subtype localized to human chromosome 4 (the pharmacologic α 2C AR subtype)
within an intracellular domain has been identified in normal individuals. The polymorphism
(denoted Del322–325) is because of an in-frame 12-nucleic acid deletion encoding a
receptor lacking Gly-Ala-Gly-Pro in the third intracellular loop. To delineate the functional …
