Prions: health scare and biological challenge
A Aguzzi, F Montrasio, PS Kaeser - Nature reviews Molecular cell …, 2001 - nature.com
A Aguzzi, F Montrasio, PS Kaeser
Nature reviews Molecular cell biology, 2001•nature.comAlthough human prion diseases are rare, the incidence of'new variant'Creutzfeldt? Jakob
disease in the United Kingdom is increasing exponentially. Given that this disease is
probably the result of infection with bovine prions, understanding how prions replicate? and
how to counteract their action? has become a central issue for public health. What are the
links between the bovine and human prion diseases, and how do prions reach and damage
the central nervous system?
disease in the United Kingdom is increasing exponentially. Given that this disease is
probably the result of infection with bovine prions, understanding how prions replicate? and
how to counteract their action? has become a central issue for public health. What are the
links between the bovine and human prion diseases, and how do prions reach and damage
the central nervous system?
Abstract
Although human prion diseases are rare, the incidence of 'new variant' Creutzfeldt?Jakob disease in the United Kingdom is increasing exponentially. Given that this disease is probably the result of infection with bovine prions, understanding how prions replicate ? and how to counteract their action ? has become a central issue for public health. What are the links between the bovine and human prion diseases, and how do prions reach and damage the central nervous system?
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