[HTML][HTML] Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons
X Roucou, Q Guo, Y Zhang, CG Goodyer… - Journal of Biological …, 2003 - ASBMB
Recently, it was observed that reverse-translocated cytosolic PrP and PrP expressed in the
cytosol induce rapid death in neurons (Ma, J., Wollmann, R., and Lindquist, S.(2002)
Science 298, 1781–1785). In this study, we investigated whether accumulation of prion
protein (PrP) in the cytosol is toxic to human neurons in primary culture. We show that in
these neurons, a single PrP isoform lacking signal peptide accumulates in the cytosol of
neurons treated with epoxomicin, a specific proteasome inhibitor. Therefore, endogenously …
cytosol induce rapid death in neurons (Ma, J., Wollmann, R., and Lindquist, S.(2002)
Science 298, 1781–1785). In this study, we investigated whether accumulation of prion
protein (PrP) in the cytosol is toxic to human neurons in primary culture. We show that in
these neurons, a single PrP isoform lacking signal peptide accumulates in the cytosol of
neurons treated with epoxomicin, a specific proteasome inhibitor. Therefore, endogenously …