Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
H Kasai - Mutation Research/Reviews in Mutation Research, 1997 - Elsevier
8-hydroxy-2′-deoxyguanosine (8-OH-dG) was first reported in 1984 as a major form of
oxidative DNA damage product by heated sugar, Fenton-type reagents and X-irradiation in
vitro. 8-OH-dG has been detected in cellular DNA using an HPLC-ECD method in many
laboratories. Analyses of 8-OH-dG in animal organ DNA after the administration of oxygen
radical-forming chemicals will be useful for assessments of their carcinogenic risk. Its
analysis in human leucocyte DNA and in urine is a new approach to the assessment of an …
oxidative DNA damage product by heated sugar, Fenton-type reagents and X-irradiation in
vitro. 8-OH-dG has been detected in cellular DNA using an HPLC-ECD method in many
laboratories. Analyses of 8-OH-dG in animal organ DNA after the administration of oxygen
radical-forming chemicals will be useful for assessments of their carcinogenic risk. Its
analysis in human leucocyte DNA and in urine is a new approach to the assessment of an …
