[PDF][PDF] Expressions of vascular endothelial growth factor and angiopoietin-2 in myeloma cells
S Uneda, F Matsuno, T Sonoki, I Tniguchi… - …, 2003 - haematologica.org
S Uneda, F Matsuno, T Sonoki, I Tniguchi, F Kawano, H Hata
Haematologica, 2003•haematologica.orgExpression of vascular endothelial growth factor and angiopoietin-2 in myeloma cells Page 1
ES subclone. Thus, the induction of HO-1 was merely a sign of oxidative stress. Nitric oxide is a
powerful inducer of HO-1,8 and this was shown in the present study. However, it did not offer
any protection against apoptosis induced by oxidative stress. Theoretically, nitric oxide may
increase the induced apoptosis, since it may react with the superoxides formed during
BSO/etoposide exposure, leading to peroxinitrate radical formation, which itself is toxic for …
ES subclone. Thus, the induction of HO-1 was merely a sign of oxidative stress. Nitric oxide is a
powerful inducer of HO-1,8 and this was shown in the present study. However, it did not offer
any protection against apoptosis induced by oxidative stress. Theoretically, nitric oxide may
increase the induced apoptosis, since it may react with the superoxides formed during
BSO/etoposide exposure, leading to peroxinitrate radical formation, which itself is toxic for …
Acknowledgments: we thank Mrs. Raija Sirviö, Satu Koljonen and Terttu Niemelä for technical assistance. Funding: this study was supported by the University Hospital of Oulu.
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