Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase Differentially Regulate Interleukin 2 Secretion and Activation Signal Pathways Involving Vav in T Cells (∗)
DW McKenney, H Onodera, L Gorman, T Mimura… - Journal of Biological …, 1995 - ASBMB
The CD45 family of transmembrane protein-tyrosine phosphatases plays a crucial role in the
regulation of lymphocyte activation by coupling activation signals from antigen receptors to
the signal transduction apparatus. Multiple CD45 isoforms, generated through regulated
alternative mRNA splicing, differ only in the length and glycosylation of their extracellular
domains. Differential distribution of these isoforms defines subsets of T cells having distinct
functions and activation requirements. While the requirement for the intracellular protein …
regulation of lymphocyte activation by coupling activation signals from antigen receptors to
the signal transduction apparatus. Multiple CD45 isoforms, generated through regulated
alternative mRNA splicing, differ only in the length and glycosylation of their extracellular
domains. Differential distribution of these isoforms defines subsets of T cells having distinct
functions and activation requirements. While the requirement for the intracellular protein …
