[HTML][HTML] β2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or Gβγ in adult mouse cardiomyocytes
M Zheng, SJ Zhang, WZ Zhu, B Ziman… - Journal of Biological …, 2000 - ASBMB
Increasing evidence shows that stimulation of β-adrenergic receptor (AR) activates mitogen-
activated protein kinases (MAPKs), in addition to the classical G s-adenylyl cyclase-cAMP-
dependent protein kinase (PKA) signaling cascade. In the present study, we demonstrate a
novel β 2-AR-mediated cross-talk between PKA and p38 MAPK in adult mouse cardiac
myocytes expressing β 2-AR, with a null background of β 1 β 2-AR double knockout. β 2-AR
stimulation by isoproterenol increased p38 MAPK activity in a time-and dose-dependent …
activated protein kinases (MAPKs), in addition to the classical G s-adenylyl cyclase-cAMP-
dependent protein kinase (PKA) signaling cascade. In the present study, we demonstrate a
novel β 2-AR-mediated cross-talk between PKA and p38 MAPK in adult mouse cardiac
myocytes expressing β 2-AR, with a null background of β 1 β 2-AR double knockout. β 2-AR
stimulation by isoproterenol increased p38 MAPK activity in a time-and dose-dependent …