Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients
J Drulović, M Mostarica-Stojković, Z Lević… - Journal of the …, 1997 - Elsevier
Concentrations of interleukin (IL)-12 and tumor necrosis factor-α (TNF-α) in cerebrospinal
fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with
non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent
assay. TNF-α was detectable in the CSF of 60% of the patients with active MS, none of those
with inactive MS and 29% of patients with NIND. CSF concentrations of TNF-α correlated
with the degree of disability in MS patients (P< 0.05). Detectable levels of IL-12 were found …
fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with
non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent
assay. TNF-α was detectable in the CSF of 60% of the patients with active MS, none of those
with inactive MS and 29% of patients with NIND. CSF concentrations of TNF-α correlated
with the degree of disability in MS patients (P< 0.05). Detectable levels of IL-12 were found …