[HTML][HTML] TGF-β induces Foxp3+ T-regulatory cells from CD4+ CD25− precursors
S Fu, N Zhang, AC Yopp, D Chen, M Mao… - American Journal of …, 2004 - Elsevier
Abstract CD4+ CD25+ regulatory T cells (Tregs) are potent suppressors, playing important
roles in autoimmunity and transplantation tolerance. Understanding the signals necessary
for the generation and expansion of Tregs is important for clinical cellular therapy, but only
limited progress has been made. Recent reports suggest a role for TGF-β in the generation
of Tregs from CD4+ CD25− precursors, but the mechanism remains unknown. Here, we
demonstrate that TGF-β2 triggers Foxp3 expression in CD4+ CD25− precursors, and these …
roles in autoimmunity and transplantation tolerance. Understanding the signals necessary
for the generation and expansion of Tregs is important for clinical cellular therapy, but only
limited progress has been made. Recent reports suggest a role for TGF-β in the generation
of Tregs from CD4+ CD25− precursors, but the mechanism remains unknown. Here, we
demonstrate that TGF-β2 triggers Foxp3 expression in CD4+ CD25− precursors, and these …
