The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments
RK Barth, BS Kim, NC Lan, T Hunkapiller, N Sobieck… - Nature, 1985 - nature.com
Nature, 1985•nature.com
Only 10 different V β gene segments were found when the sequences of 15 variable (V β)
genes of the mouse T-cell receptor were examined. From this analysis we calculate that the
total number of expressed V β gene segments may be 21 or fewer, which makes the
expressed germline V β repertoire much smaller than that of the immunoglobulin heavy-
chain or light-chain genes. We suggest that β chain somatic diversification is concentrated at
the V β− D β− J β junctions.
genes of the mouse T-cell receptor were examined. From this analysis we calculate that the
total number of expressed V β gene segments may be 21 or fewer, which makes the
expressed germline V β repertoire much smaller than that of the immunoglobulin heavy-
chain or light-chain genes. We suggest that β chain somatic diversification is concentrated at
the V β− D β− J β junctions.
Abstract
Only 10 different Vβ gene segments were found when the sequences of 15 variable (Vβ) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed Vβ gene segments may be 21 or fewer, which makes the expressed germline Vβ repertoire much smaller than that of the immunoglobulin heavy-chain or light-chain genes. We suggest that βchain somatic diversification is concentrated at the Vβ−Dβ−Jβ junctions.
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