Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is
synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and
enzymes that are involved in PS biosynthesis in bacteria, yeast, plants and mammalian cells
and discuss the available information on the regulation of PS biosynthesis in these
organisms. The enzymes that synthesize PS are restricted to endoplasmic reticulum
membranes in yeast and mammalian cells, yet PS is widely distributed throughout other …