Somatostatin, and the recently discovered neuropeptide cortistatin, exert their physiological
actions via a family of six G protein-coupled receptors (sst1, sst2A, sst2B, sst3, sst4, sst5).
Following the cloning of somatostatin receptors significant advances have been made in our
understanding of their molecular, pharmacological and signaling properties although much
progress remains to be done to define their physiological role in vivo. In this review, the
present knowledge regarding neuroanatomical localization, signal transduction pathways …