Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants: a quantitative study in knockout mice lacking the LDL receptor …
S Ishibashi, S Perrey, Z Chen, J Osuga… - Journal of Biological …, 1996 - ASBMB
Two receptor pathways are thought to mediate the hepatic clearance of chylomicron
remnants,(i) the low density lipoprotein receptor (LDLR) pathway and (ii) non-LDLR
pathway. The current study was undertaken to quantitatively assess the contribution of each
receptor pathway to hepatic catabolism of chylomicron remnants, by using mice that are
deficient in apolipoprotein E (apoE)(apoE (-/-)), the LDLR (LDLR (-/-)), and both (apoE (-/-);
LDLR (-/-)). Vitamin A fat tolerance tests showed that the area under the curves of the …
remnants,(i) the low density lipoprotein receptor (LDLR) pathway and (ii) non-LDLR
pathway. The current study was undertaken to quantitatively assess the contribution of each
receptor pathway to hepatic catabolism of chylomicron remnants, by using mice that are
deficient in apolipoprotein E (apoE)(apoE (-/-)), the LDLR (LDLR (-/-)), and both (apoE (-/-);
LDLR (-/-)). Vitamin A fat tolerance tests showed that the area under the curves of the …
