[HTML][HTML] Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor …
LO Mosnier, XV Yang, JH Griffin - Journal of biological chemistry, 2007 - ASBMB
Activated protein C (APC) reduces mortality in severe sepsis patients and exhibits beneficial
effects in multiple animal injury models. APC anticoagulant activity involves inactivation of
factors Va and VIIIa, whereas APC cytoprotective activities involve the endothelial protein C
receptor and protease-activated receptor-1 (PAR-1). The relative importance of the
anticoagulant activity of APC versus the direct cytoprotective effects of APC on cells for the in
vivo benefits is unclear. To distinguish cytoprotective from the anticoagulant activities of …
effects in multiple animal injury models. APC anticoagulant activity involves inactivation of
factors Va and VIIIa, whereas APC cytoprotective activities involve the endothelial protein C
receptor and protease-activated receptor-1 (PAR-1). The relative importance of the
anticoagulant activity of APC versus the direct cytoprotective effects of APC on cells for the in
vivo benefits is unclear. To distinguish cytoprotective from the anticoagulant activities of …
