Interaction of the fibrinolytic receptor, annexin II, with the endothelial cell surface: essential role of endonexin repeat 2
KA Hajjar, CA Guevara, E Lev, K Dowling… - Journal of Biological …, 1996 - ASBMB
Endothelial cells express a cell surface co-receptor for plasminogen and tissue plasminogen
activator (t-PA) which we recently identified as annexin II (Hajjar, KA, Jacovina, AT, and
Chacko, J.(1994) J. Biol. Chem. 269, 21191-21197). This protein enhances the catalytic
efficiency of t-PA-dependent plasmin generation by 60-fold (Cesarman, GM, Guevara, CA,
and Hajjar, KA (1994) J. Biol. Chem. 269, 21198-21203). Here, we demonstrate that annexin
II is constitutively translocated to the endothelial cell surface within 16 h of biosynthesis, and …
activator (t-PA) which we recently identified as annexin II (Hajjar, KA, Jacovina, AT, and
Chacko, J.(1994) J. Biol. Chem. 269, 21191-21197). This protein enhances the catalytic
efficiency of t-PA-dependent plasmin generation by 60-fold (Cesarman, GM, Guevara, CA,
and Hajjar, KA (1994) J. Biol. Chem. 269, 21198-21203). Here, we demonstrate that annexin
II is constitutively translocated to the endothelial cell surface within 16 h of biosynthesis, and …
