[HTML][HTML] Fgfr4 is required for effective muscle regeneration in vivo: Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway
PO Zhao, G Caretti, S Mitchell, WL McKeehan… - Journal of Biological …, 2006 - ASBMB
Fgfr4 has been shown to be important for appropriate muscle development in chick limb
buds; however, Fgfr4 null mice show no phenotype. Here, we show that staged induction of
muscle regeneration in Fgfr4 null mice becomes highly abnormal at the time point when
Fgfr4 is normally expressed. By 7 days of regeneration, differentiation of myotubes became
poorly coordinated and delayed by both histology and embryonic myosin heavy chain
staining. By 14 days much of the muscle was replaced by fat and calcifications. To begin to …
buds; however, Fgfr4 null mice show no phenotype. Here, we show that staged induction of
muscle regeneration in Fgfr4 null mice becomes highly abnormal at the time point when
Fgfr4 is normally expressed. By 7 days of regeneration, differentiation of myotubes became
poorly coordinated and delayed by both histology and embryonic myosin heavy chain
staining. By 14 days much of the muscle was replaced by fat and calcifications. To begin to …
