An update on clinical and basic aspects of the protein C anticoagulant pathway
CT Esmon, HP Schwarz - Trends in cardiovascular medicine, 1995 - Elsevier
The protein C anticoagulant pathway provides a mechanism for regulating the coagulation
process through the selective inactivation of factors Va and VIIIa. Recent studies have
suggested that factor V may facilitate this process and that a mutation at one of the
inactivation sites can contribute to resistance to activated protein C (APC) inactivation of
factor Va. This appears to be a common cause of familial thrombophilia. The control
mechanisms involved in factor Va inactivation have also begun to become more clear …
process through the selective inactivation of factors Va and VIIIa. Recent studies have
suggested that factor V may facilitate this process and that a mutation at one of the
inactivation sites can contribute to resistance to activated protein C (APC) inactivation of
factor Va. This appears to be a common cause of familial thrombophilia. The control
mechanisms involved in factor Va inactivation have also begun to become more clear …
