[HTML][HTML] Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ …
The phosphorylation of the cardiac Ca 2+-release channel (ryanodine receptor, RyR2) by
protein kinase A (PKA) has been extensively characterized, but its functional consequence
remains poorly defined and controversial. We have previously shown that RyR2 is
phosphorylated by PKA at two major sites, serine 2030 and serine 2808, of which Ser-2030
is the major PKA site responding to β-adrenergic stimulation. Here we investigated the effect
of the phosphorylation of RyR2 by PKA on the properties of single channels and on …
protein kinase A (PKA) has been extensively characterized, but its functional consequence
remains poorly defined and controversial. We have previously shown that RyR2 is
phosphorylated by PKA at two major sites, serine 2030 and serine 2808, of which Ser-2030
is the major PKA site responding to β-adrenergic stimulation. Here we investigated the effect
of the phosphorylation of RyR2 by PKA on the properties of single channels and on …
