Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
JA Parker, M Arango, S Abderrahmane, E Lambert… - Nature …, 2005 - nature.com
Nature genetics, 2005•nature.com
We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin
activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by
mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent
on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine–specific cell
death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2
activation may protect against mutant polyglutamines.
activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by
mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent
on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine–specific cell
death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2
activation may protect against mutant polyglutamines.
Abstract
We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine–specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.
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