The TREM-1/DAP12 pathway
AS Tessarz, A Cerwenka - Immunology letters, 2008 - Elsevier
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation
motif (ITAM)-bearing adapter, which couples to multiple receptors expressed on natural killer
(NK) cells, monocytes, and neutrophils. Initially, DAP12-mediated signaling was mainly
investigated downstream of receptors expressed on NK cells. In myeloid cells, one of the
receptors associating with DAP12 is the triggering receptor expressed on myeloid cells
(TREM)-1. Since the real nature of TREM-1L (s) is still illusive, TREM-1 biology was so far …
motif (ITAM)-bearing adapter, which couples to multiple receptors expressed on natural killer
(NK) cells, monocytes, and neutrophils. Initially, DAP12-mediated signaling was mainly
investigated downstream of receptors expressed on NK cells. In myeloid cells, one of the
receptors associating with DAP12 is the triggering receptor expressed on myeloid cells
(TREM)-1. Since the real nature of TREM-1L (s) is still illusive, TREM-1 biology was so far …
