Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response
K Kofoed, J Gerstoft, LR Mathiesen… - Sexually transmitted …, 2006 - journals.lww.com
K Kofoed, J Gerstoft, LR Mathiesen, T Benfield
Sexually transmitted diseases, 2006•journals.lww.comObjectives: To assess the effect of human immunodeficiency virus (HIV)-1 and syphilis
coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in
rapid plasmin reagin (RPR) to treatment of the syphilis infection. Study Design: Cases of
syphilis diagnosed during 1 year in HIV-infected patients in Copenhagen were included. HIV-
RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis.
Results: Forty-one patients were included. CD4 cell count decreased significantly during …
coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in
rapid plasmin reagin (RPR) to treatment of the syphilis infection. Study Design: Cases of
syphilis diagnosed during 1 year in HIV-infected patients in Copenhagen were included. HIV-
RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis.
Results: Forty-one patients were included. CD4 cell count decreased significantly during …
Objectives:
To assess the effect of human immunodeficiency virus (HIV)-1 and syphilis coinfection on HIV-ribonucleic acid (RNA) viral load, CD4 cell count, and the response in rapid plasmin reagin (RPR) to treatment of the syphilis infection.
Study Design:
Cases of syphilis diagnosed during 1 year in HIV-infected patients in Copenhagen were included. HIV-RNA, CD4 cell counts, and RPR-serology were measured before, during, and after syphilis.
Results:
Forty-one patients were included. CD4 cell count decreased significantly during infection in patients with primary and secondary stages of syphilis (mean 106 cells/mm 3, P= 0.03). Treatment of syphilis was associated with an increase in the CD4 cell count and a decrease in HIV-RNA in the overall group (mean 66 cells/mm 3 and− 0.261 RNA log 10 copies/ml, P= 0.02 and 0.04). The serological response rates for 15 patients treated with penicillin and 25 treated with doxycycline were the same.
Conclusion:
Syphilis was associated with a decrease in CD4 cell counts and an increase in HIV-RNA levels that both improved after treatment of syphilis.
Lippincott Williams & Wilkins