The Oslo study of the natural history of untreated syphilis: an epidemiologic investigation based on a restudy of the Boeck-Bruusgaard material a review and appraisal

EG Clark, N Danbolt - Journal of chronic diseases, 1955 - Elsevier
Nowhere in the world is there a more unique opportunity to learn what happens when early
syphilis goes untreated than from the files of Boeck of Oslo, Norway. His scientific conviction
as to the inadequacies of the specific treatment of the day led him to withhold treatment from
approximately 2,000 patients with primary and secondary syphilis during the twenty-year
period, 1891–1910. Community protection from infection was aided by the hospitalization of
these patients until all traces of the disease had disappeared (from 1 to 12 months, average …