Treponema pallidum Fibronectin-Binding Proteins
CE Cameron, EL Brown, JMY Kuroiwa… - Journal of …, 2004 - Am Soc Microbiol
CE Cameron, EL Brown, JMY Kuroiwa, LM Schnapp, NL Brouwer
Journal of bacteriology, 2004•Am Soc MicrobiolPutative adhesins were predicted by computer analysis of the Treponema pallidum genome.
Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to
fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported
attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and
Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions.
Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to
fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported
attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and
Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions.
Abstract
Putative adhesins were predicted by computer analysis of the Treponema pallidum genome. Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions.
American Society for Microbiology