Actin dynamics determines podocyte morphology during development and in response to
podocyte injury and might be necessary for maintaining normal podocyte morphology.
Because podocyte intercellular junction receptor Nephrin plays a role in regulating actin
dynamics, and given the described role of cofilin in actin filament polymerization and
severing, we hypothesized that cofilin-1 activity is regulated by Nephrin and is necessary in
normal podocyte actin dynamics. Nephrin activation induced cofilin dephosphorylation via …