[HTML][HTML] Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration
NY Shin, RS Dise, J Schneider-Mergener… - Journal of Biological …, 2004 - ASBMB
Crk-associated substrate (p130 CAS or CAS) is a major integrin-associated Src substrate
that undergoes tyrosine phosphorylation at multiple YXXP motifs in its substrate domain
(SD) to create docking sites for SH2-containing signaling effectors. Notably, recruitment of
Crk adaptor proteins to the CAS SD sites is implicated in promoting cell migration. However,
it is unclear which or how many of the 15 CAS SD YXXP tyrosines are critically involved. To
gain a better understanding of CAS SD function, we assessed the signaling capacity of …
that undergoes tyrosine phosphorylation at multiple YXXP motifs in its substrate domain
(SD) to create docking sites for SH2-containing signaling effectors. Notably, recruitment of
Crk adaptor proteins to the CAS SD sites is implicated in promoting cell migration. However,
it is unclear which or how many of the 15 CAS SD YXXP tyrosines are critically involved. To
gain a better understanding of CAS SD function, we assessed the signaling capacity of …