[HTML][HTML] The integrin α7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk coupling
D Mielenz, S Hapke, E Pöschl, H von der Mark… - Journal of Biological …, 2001 - ASBMB
The integrin α 7 β 1 is the major laminin-binding integrin in skeletal, heart, and smooth
muscle and is a receptor for laminin-1 and-2. It mediates myoblast migration on laminin-1
and-2 and thus might be involved in muscle development and repair. Previously we have
shown that α 7 B as well as the α 7 A and-C splice variants induce cell motility on laminin
when transfected into nonmotile HEK293 cells. In this study we have investigated the role of
the cytoplasmic domain of α 7 in the laminin-induced signal transduction of α 7 β 1 integrin …
muscle and is a receptor for laminin-1 and-2. It mediates myoblast migration on laminin-1
and-2 and thus might be involved in muscle development and repair. Previously we have
shown that α 7 B as well as the α 7 A and-C splice variants induce cell motility on laminin
when transfected into nonmotile HEK293 cells. In this study we have investigated the role of
the cytoplasmic domain of α 7 in the laminin-induced signal transduction of α 7 β 1 integrin …