Transgenic manipulation of the glomerular visceral epithelial cell offers a powerful approach
for studying the biology of this morphologically complex cell type. It has been previously
demonstrated that an 8.3-kb and a 5.4-kb fragment of the murine Nphs1 (nephrin) promoter-
enhancer drives lacZ expression in podocytes, brain, and pancreas of transgenic mice,
recapitulating the expression pattern of the endogenous nephrin gene. In this present study,
two truly podocyte-specific promoters were identified that drive transgene expression in …