Premature aging-related peripheral neuropathy in a mouse model of progeria
JR Goss, DB Stolz, AR Robinson, M Zhang… - Mechanisms of ageing …, 2011 - Elsevier
Peripheral neuropathy is a common aging-related degenerative disorder that interferes with
daily activities and leads to increased risk of falls and injury in the elderly. The etiology of
most aging-related peripheral neuropathy is unknown. Inherited defects in several genome
maintenance mechanisms cause tissue-specific accelerated aging, including
neurodegeneration. We tested the hypothesis that a murine model of XFE progeroid
syndrome, caused by reduced expression of ERCC1-XPF DNA repair endonuclease …
daily activities and leads to increased risk of falls and injury in the elderly. The etiology of
most aging-related peripheral neuropathy is unknown. Inherited defects in several genome
maintenance mechanisms cause tissue-specific accelerated aging, including
neurodegeneration. We tested the hypothesis that a murine model of XFE progeroid
syndrome, caused by reduced expression of ERCC1-XPF DNA repair endonuclease …