Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving Device

PV Sackey, CR Martling, F Granath… - Critical care …, 2004 - journals.lww.com
Objective: To test the efficacy and patient safety of a new method for administering isoflurane
for prolonged sedation in the intensive care unit. Design: Randomized controlled trial.
Setting: Multidisciplinary university intensive care unit, January 2002 to July 2003. Patients:
Forty ventilator-dependent intensive care unit patients 18–80 yrs old, expected to need> 12
hrs sedation. Interventions: Patients were randomized to sedation with inhaled isoflurane via
the Anesthetic Conserving Device or intravenous midazolam infusion. Study duration was …