[HTML][HTML] Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment
JP Lévesque, J Hendy, Y Takamatsu, B Williams… - Experimental …, 2002 - Elsevier
OBJECTIVE: Hematopoietic stem and progenitor cells normally reside in the bone marrow
but can be mobilized into the peripheral blood following treatment with granulocyte colony-
stimulating factor (G-CSF) or myelosuppressive chemotherapy. Although the number of
transplants performed with mobilized blood currently exceeds those performed with bone
marrow, little is known of the molecular mechanisms responsible for this phenomenon. We
sought to determine whether mobilization induced by G-CSF or chemotherapy was triggered …
but can be mobilized into the peripheral blood following treatment with granulocyte colony-
stimulating factor (G-CSF) or myelosuppressive chemotherapy. Although the number of
transplants performed with mobilized blood currently exceeds those performed with bone
marrow, little is known of the molecular mechanisms responsible for this phenomenon. We
sought to determine whether mobilization induced by G-CSF or chemotherapy was triggered …
