Investigation of age-related cognitive decline using mice as a model system: behavioral correlates
Objective With recent advances in molecular genetics, mouse models have been generated
for a number of disease states. Recently, the authors and others have begun to examine
normal age-related cognitive decline using mice as a model system. In this article, and the
companion article that follows, the authors present data intended to better parameterize the
aging phenotype in mice and examine the possible underlying neuronal mechanisms with
special emphasis on age-related changes in calcium homeostasis. Methods Young (4–6 …
for a number of disease states. Recently, the authors and others have begun to examine
normal age-related cognitive decline using mice as a model system. In this article, and the
companion article that follows, the authors present data intended to better parameterize the
aging phenotype in mice and examine the possible underlying neuronal mechanisms with
special emphasis on age-related changes in calcium homeostasis. Methods Young (4–6 …