Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model
Breast cancer is the most common cancer type for women in the western world. Despite
decades of research, the molecular processes associated with breast cancer progression
are still inadequately defined. Here, we focus on the systematic alteration of metabolism by
using the state of the art metabolomic profiling techniques to investigate the changes of 157
metabolites during the progression of normal mouse mammary epithelial cells to an isogenic
series of mammary tumor cell lines with increasing metastatic potentials. Our results suggest …
decades of research, the molecular processes associated with breast cancer progression
are still inadequately defined. Here, we focus on the systematic alteration of metabolism by
using the state of the art metabolomic profiling techniques to investigate the changes of 157
metabolites during the progression of normal mouse mammary epithelial cells to an isogenic
series of mammary tumor cell lines with increasing metastatic potentials. Our results suggest …
