Personal mouse colonies give hope for pancreatic cancer patients
K Garber - Journal of the National Cancer Institute, 2007 - academic.oup.com
K Garber
Journal of the National Cancer Institute, 2007•academic.oup.comSimilar tests for guiding therapy, called chemoresistance assays and chemosensitivity
assays, usually involve testing drugs in vitro against the patient's isolated tumor cells
obtained from surgery or biopsy.(A few involved mouse tumor models.) Two careful reviews,
published in the Sept. 1, 2004, issue of the Journal of Clinical Oncology, concluded that
randomized trials are still needed to demonstrate that these assays work. Although several
studies did show a higher response rate for assay-guided therapy than physicianguided …
assays, usually involve testing drugs in vitro against the patient's isolated tumor cells
obtained from surgery or biopsy.(A few involved mouse tumor models.) Two careful reviews,
published in the Sept. 1, 2004, issue of the Journal of Clinical Oncology, concluded that
randomized trials are still needed to demonstrate that these assays work. Although several
studies did show a higher response rate for assay-guided therapy than physicianguided …
Similar tests for guiding therapy, called chemoresistance assays and chemosensitivity assays, usually involve testing drugs in vitro against the patient’s isolated tumor cells obtained from surgery or biopsy.(A few involved mouse tumor models.) Two careful reviews, published in the Sept. 1, 2004, issue of the Journal of Clinical
Oncology, concluded that randomized trials are still needed to demonstrate that these assays work. Although several studies did show a higher response rate for assay-guided therapy than physicianguided therapy, few resulted in a survival advantage.“There does not appear to be a single assay that is ready for routine integration into the clinical setting,” concluded one of the reviews, by a American Society of Clinical Oncology (ASCO) working group.
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