Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis
X Ma, L Xu, S Wang, B Cui, X Li, J Xu, G Ning - Journal of hepatology, 2011 - Elsevier
BACKGROUND & AIMS: Excess dietary fat can cause hepatic steatosis, which can progress
into severe liver disorders including steatohepatitis and cirrhosis. Steroid receptor
coactivator-3 (SRC-3), a member of the p160 coactivator family, is reported as a key
regulator of adipogenesis and energy homeostasis. We sought to determine the influence of
SRC-3 on hepatic steatosis and the mechanism beneath. METHODS: The influence of
siRNA-mediated SRC-3 silencing on hepatic lipid accumulation was assessed in HepG2 …
into severe liver disorders including steatohepatitis and cirrhosis. Steroid receptor
coactivator-3 (SRC-3), a member of the p160 coactivator family, is reported as a key
regulator of adipogenesis and energy homeostasis. We sought to determine the influence of
SRC-3 on hepatic steatosis and the mechanism beneath. METHODS: The influence of
siRNA-mediated SRC-3 silencing on hepatic lipid accumulation was assessed in HepG2 …
