TRP channels form a superfamily of channel proteins exhibiting versatile regulatory
characteristics with many channels participating in the regulation of Ca2+ homeostasis and
influencing the cell fate. Multitude of evidence is emerging that the colocalization of TRP
channels with Ca2+-sensing elements of specific regulatory pathways leading to either
proliferation or apoptosis is what makes these channels participate in cell fate regulation
and, in turn, determines the final effect of Ca2+ entry via the particular channel. This review …